In this short post we’ll look at the various clinical uses of Botulinum Toxin injections or Botox®. Blepharospasm It’s a condition which causes excessive blinking an eye closure with difficulty opening the eyes made worse by bright light and can be very disabling causing problems with eating, conversation and even driving. Cervical dystonia abnormal head posturing or pulling with the tightness of neck muscles commonly associated with neck pain. This can result in twisting and turning of the head in …
Category: Botulinum Toxin
What is Botulinum Toxin anyway? What is Botox given for? How was it discovered? What does it look like? How does it work? How long does it last? Have you ever wondered about these questions? Let’s have a look. Botulinum Toxin was discovered due to sausage poisoning from under cooked food in the time of Napoleonic wars from food shortage. Later on, we discovered the Botulinum toxin bacterium that makes this toxin, purified toxin and found its various serotypes and …
Structure: BTX is synthesized as a single-chain peptide with a molecular mass of 150 kilodaltons. This form has relatively little potency as a neuromuscular blocking agent, and activation requires a 2-step modification in the tertiary structure of the protein. This process converts the single-chain neurotoxin to a di-chain neurotoxin comprising a 100,000-dalton heavy chain (HC) linked by a disulfide bond to a 50,000-dalton light chain (LC). BTX acts at the neuromuscular junction where it exerts its effect by inhibiting the …
Here are some pro tips. Tips for the professionals who are doing botulinum toxin injections. These are advanced tips and not necessarily make sense if you don’t have a good background in Dystonia and use of botulinum toxin injections. So be mindful of that. So these are things mostly that were new to me. Blepharospasm: Itis a focal dystonia, and treatment of choice botulinum toxin injection. There are no other drugs that have shown benefit in blepharospasm treatment. However there …
I would divide this into three sections. What would you do before seeing your patients for the injections. What would you do on the injection day and what would you do after the injection day. So let’s look at the first segment. The first thing you should do is develop templates and notes. The documentation is highly important in doing a good injection and also for following up on your response injection and improving your injection results. So you should …
